| Huabing Chen, Ph. D., Prof. Principle Investigator College of Pharmaceutical Sciences Soochow University
|
Address: 1331, Yunxuan Building, Soochow University
Ren’ai Road 199, Suzhou215123, China
Email: chenhb@suda.edu.cn
B. Sc. in Chemical Engineering, 2001, Huazhong University of Science & Technology
M. Sc. in Inorganic Chemistry, 2004, Huazhong University of Science & Technology
Ph. D. in Biopharmaceutical Engineering, 2008, Huazhong University of Science & Technology
Postdoc, 2008-2010, University of Texas Southwestern Medical Center at Dallas
Postdoc, 2010-2012, University of Tokyo
Professor, 2012-present, College of Pharmaceutical Sciences, Soochow University
Pharmaceutics, Nanomedicine, Pharmaceutical Research Progress
National NaturalScience Foundation of China for Excellent Young Scholars, 2015-2017
Double Innovative Program of Jiangsu Province, 2015-2017
1. Biomimetic protein nanoparticles for cancer imaging and therapy
2. Smart polymeric nanoparticles for cancer imaging and targeted therapy
3. Self-assembled nanoparticles for photo-induced cancer therapy
4. Development of novel dosage forms
1. Y Deng, L Huang, H Yang*, H Ke, H He, Z Guo, T Yang, A Zhu, H. Wu*, H Chen*. Cyanine-anchored Silica Nanochannels for Light-driven SynergisticThermo-chemotherapy. Small. 2016, DOI: 10.1002/smll.201602747
2. Z Guo, Y Zou, H He, J Rao, S Ji, X Cui, H Ke, Y Deng, H Yang, C Chen, Y Zhao, and H Chen*. Bifunctional Platinated Nanoparticles for PhotoinducedTumor Ablation. Adv. Mater. 2016, DOI: 10.1002/adma.201602738
3. T Yang, Y Wang, H Ke, Q Wang, X Lv, H Wu, Y Tang, X Yang, C Chen, Y Zhao, and H Chen*. Protein-Nanoreactor-Assisted Synthesis of SemiconductorNanocrystals for Efficient Cancer Theranostics. Adv. Mater. 2016, 28(28): 5923-5930.
4. X An, A Zhu, H Luo, H Ke, H Chen*, and Y Zhao*. Rational Designof Multi-Stimuli-Responsive Nanoparticles for Precise Cancer Therapy. ACS Nano. 2016, 10(6): 5947-5958.
5. Y Ma, J Huang, S Song, H Chen*, and Z Zhang*. Cancer-TargetedNanotheranostics: Recent Advances and Perspectives. Small. 2016, 12(36): 4936-4954.
6. X Ai, C J H Ho, J Aw, A B E Attia, J Mu, Y Wang, X Wang, Y Wang, X Liu, H Chen, M Gao, X Chen, E K L Yeow, G Liu, M Olivo, and B Xing*. In Vivo Covalent Cross-linking of Photon-converted Rare-earth Nanostructures for Tumour Localization and Theranostics. Nat. Commun. 2016, (7): 10432.
7. Y Li, Y Deng, X Tian, H Ke*, MGuo, A Zhu, T Yang, Z Guo, Z Ge, X Yang, and H Chen*. Multipronged Design of Light-Triggered Nanoparticles to Overcome Cisplatin Resistance for Efficient Ablation of Resistant Tumor. ACS Nano. 2015, 9(10): 9626-9637.
8. A Zhu, K Miao, Y Deng, H Ke, H He, T Yang, M Guo, Y Li, ZGuo, Y Wang, X Yang, Y Zhao*, and H Chen*. Dually pH/Reduction-Responsive Vesicles for Ultrahigh-Contrast Fluorescence Imaging and Thermo-Chemotherapy-Synergized Tumor Ablation. ACS Nano. 2015, 9(8):7874-7885.
9. Y Wang, T Yang, H Ke, A Zhu, Y Wang, J Wang, J Shen, G Liu, C Chen, Y Zhao, and H Chen*. Smart Albumin-Biomineralized Nanocomposites for Multimodal Imaging and Photothermal Tumor Ablation. Adv. Mater. 2015, 27(26): 3874-3882.
10. J Huang, M Guo, H Ke, C Zong, B Ren, G Liu, H Shen, Y Ma, X Wang, H Zhang, Z Deng, H Chen*, and Z Zhang*. Rational Design and Synthesis of γFe2O3@Au Magnetic Gold Nanoflowers for Efficient Cancer Theranostics. Adv. Mater.2015, 27(34):5049-5056.
11. M Guo, J Huang, Y Deng, H Shen, Y Ma, M Zhang, A Zhu, Y Li, HHui, Y Wang, X Yang, Z Zhang*, and H Chen*. pH-Responsive Cyanine-Grafted Graphene Oxide for Fluorescence Resonance Energy Transfer-Enhanced Photothermal Therapy. Adv. Funct. Mater.2015, 25(1):59-67.
12. J Li, Z Lyv, Y Li, H Liu, J Wang, W Zhan, H Chen*, and X Li*. A Theranostic Prodrug Delivery System Based on Pt(IV) Conjugated Nano-graphene Oxide with Synergistic Effect to Enhance the Therapeutic Efficacy of Pt Drug. Biomaterials. 2015, 51: 12-21.
13. H Chen, L Xiao, Y Anraku, P Mi, X Liu, H Cabral, A Inoue, T Nomoto, A Kishimura*, N Nishiyama*, and K Kataoka*. Polyion Complex Vesicles for Photoinduced Intracellular Delivery of Amphiphilic Photosensitizer. J. Am. Chem. Soc. 2014, 136(1): 157-163.
14. M Guo, H Mao, Y Li, A Zhu, H He, H Yang, Y Wang, X Tian, C Ge, Q Peng, X Wang, X Yang, X Chen, G Liu*, and H Chen*. Dual Imaging-guided Photothermal/Photodynamic Therapy Using Micelles. Biomaterials. 2014, 35(16): 4656-4666.
15. Z Wan, H Mao, M Guo, Y Li, A Zhu, H Yang, H He, J Shen, L Zhou, Z Jiang, C Ge, X Chen, X Yang, G Liu, and H Chen*. Highly Efficient Hierarchical Micelles Integrating Photothermal Therapy and Singlet Oxygen-Synergized Chemotherapy for Cancer Eradication. Theranostics. 2014, 4(4): 399-411.
16. H Yang, H Mao, Z Wan, A Zhu, M Guo, Y Li, X Li, J Wan, X Yang, X Shuai, and H Chen*. Micelles Assembled with Carbocyanine Dyes for Theranostic Near-infrared Fluorescent Cancer Imaging and Photothermal Therapy. Biomaterials. 2013, 34(36): 9124-9133.
17. G Huang#, H Chen#, Y Dong#, X Luo, H Yu, Z Moore, E A Bey, D ABoothman*, and J Gao*. Superparamagnetic Iron Oxide Nanoparticles: Amplifying ROS Stress to ImproveAnticancer Drug Efficacy. Theranostics. 2013, 3(2): 116-126.
18. H Chen, H Zhu, J Hu, Y Zhao, Q Wang, J Wan, Y Yang, H Xu, and X Yang*. Highly Compressed Assembly of Deformable Nanogels into Nanoscale Suprastructures and Their Application in Nanomedicine. ACS Nano. 2011, 5(4): 2671-2680.
19. H Chen, C Khemtong, X Yang, X Chang, and J Gao*. Nanonization Strategies for Poorly Water-soluble Drugs. Drug Discov. Today. 2011, 16(7–8): 354-360.
20. H Chen, L Xiao, D Du, D Mou, H Xu, and X Yang*. A Facile Construction Strategy of Stable Lipid Nanoparticlesfor Drug Delivery Using A Hydrogel-thickened Microemulsion System. Nanotechnology. 2010, 21(1): 015101.
21. H Chen, H Zhu, J Zheng, D Mou, J Wan, J Zhang, T Shi, Y Zhao, H Xu,and X Yang*. Iontophoresis-driven Penetration of Nanovesicles Through Microneedle-induced Skin Microchannels for Enhancing Transdermal Delivery of Insulin. J. Control. Release. 2009, 139(1): 63-72.
22. H Chen, J Wan, Y Wang, D Mou, H Liu, H Xu, and X Yang*. A FacileNanoaggregation Strategy for oral Delivery of Hydrophobic Drugs by Utilizing Acid-base Neutralization Reactions. Nanotechnology. 2008, 19(37): 375104.
23. D Mou, H Chen*, D Du, C Mao, J Wan, H Xu, and X Yang*. Hydrogel-thickened Nanoemulsion System for Topical Delivery of Lipophilic Drugs. Int. J. Pharm. 2008, 353(1–2): 270-276.
24. H Chen D Mou, D Du, X Chang, D Zhu, J Liu, H Xu, and X Yang*. Hydrogel-thickened Microemulsion for Topical Administration of Drug Molecule at An Extremely Low Concentration. Int. J.Pharm. 2007, 341(1–2): 78-84.
25. H Chen, X Chang, D Du, W Liu, J Liu, T Weng, Y Yang*, H Xu,and X Yang. Podophyllotoxin-loaded Solid Lipid Nanoparticles for Epidermal Targeting. J. Control. Release. 2006, 110(2): 296-306.
26. H Chen, X Chang, D Du, J Li, H Xu, and X Yang*. Microemulsion-based Hydrogel Formulation of Ibuprofen for Topical Delivery. Int. J. Pharm. 2006, 315(1–2): 52-58.
27. H Chen, XChang, T Weng, X Zhao, Z Gao, Y Yang, H Xu, and X Yang*. A Study of Microemulsion Systems for Transdermal Delivery of Triptolide. J. Control. Release. 2004, 98(3): 427-436.
1. H Ke, H Chen*. Chapter 10 - Multimodal Micelles for Theranostic Nanomedicine. Advances in Nanotheranostics II: CancerTheranostic Nanomedicine. Springer-Verlag, Singapore, 2016.
2. H Chen, Z Ge, K Kataoka. Chapter 4 - Polymeric Micelles for Cancer-Targeted Drug Delivery. Bioinspired and Biomimetic Systems for Drugand Gene Delivery. Chemical Industry Press and Wiley-VCH Verlag GmbH &Co. KGaA, Germany, 2015.
1. H Chen, Z Guo, Y Zou, H He, Preparation and application of theplatinum-based fluorine boron dipyrrole, Chinese Patent, CN 201610846899.8
2. H Chen, Y Deng, H Yang, H Ke, L Huang, A Zhu, Z Guo, Preparation and application of multifunctional mesoporous silica nanoparticles for near-infrared photothermal therapy and fluorescence imaging, Chinese Patent, CN 105056233A
3. H Chen, T Yang, Y Deng, Y Wang, H Ke, Z Guo, H He, H Yang, Y Zou, S Ji, Q Wang, Preparation of copper based human serum albumin nanocomposites for near-infrared photothermal therapy, Chinese Patent, CN 105106958A
4. Z Guo, H Chen, Y Zou, H He, J Rao, Preparation and application of novel platinum compounds for near-infrared photodynamic therapy, Chinese Patent, CN 105198934A
5. H Yang, H Chen, X Wu, H Liu, Z Gong, Y Gu, C Zhao, F Yao, Preparation of Imiquimod-loaded vesicle gels, Chinese Patent, CN 103202803A
6. H Yang, H Liu, H Chen, H Mao, N Han, R Gu, X Ma, Y Wu, Preparation of folic acid modified norcantharidin stealth niosomes, Chinese Patent, CN 103263388A
7 .X Yang, D Mu, X Zhou, J Wan, H Chen, H Xu, Preparation and application of itraconazole nanocrystals, Chinese Patent, CN 200910063819.1
8. X Yang, H Zhu, H Chen, H Xu, J Zhang, J Hao, Preparation of topically administered shallot extractive nanoemulsion compositions, Chinese Patent, CN 200910273099.1
9. H Chen, X Yang, H Xu, Y Yang, W Liu, X Zhou, Preparation and application of skin targeting drug composition, Chinese Patent, ZL 200410013282
10. X Yang, H Xu, W Liu, C Tang, H Chen, X Zhou, Preparation of injectable allicin-loaded emulsions, Chinese Patent, ZL 200410060815.5
1. National Natural Science Foundation of China (No. 31671016)
2. National Science Foundation for Excellent Young Scholars (No. 31422021)
3. National Natural Science Foundation of China (No. 51473109)
4. Programs for Innovation and Entrepreneurship, Jiangsu Province
5. National Natural Science Foundation of China (No. 81202472)
Soochow University
Chinese